Search results for "functional profiling"

showing 3 items of 3 documents

Unveiling Sex-Based Differences in the Effects of Alcohol Abuse: A Comprehensive Functional Meta-Analysis of Transcriptomic Studies

2020

AbstractThe abuse of alcohol, one of the most popular psychoactive substances, can cause several pathological and psychological consequences, including alcohol use disorder (AUD). An impaired ability to stop or control alcohol intake despite adverse health or social consequences characterize AUD. While AUDs predominantly occur in men, growing evidence suggests the existence of distinct cognitive and biological consequences of alcohol dependence in women. The molecular and physiological mechanisms participating in these differential effects remain unknown. Transcriptomic technology permits the detection of the biological mechanisms responsible for such sex-based differences, which supports t…

0301 basic medicinelcsh:QH426-470Alcohol DrinkingAlcohol abuseAlcohol use disorderBioinformaticsArticleTranscriptome03 medical and health sciencestranscriptomics0302 clinical medicinealcohol use disordersmental disordersGeneticsmedicineHumansPathologicalGenetics (clinical)functional profilingbusiness.industryAlcohol dependenceCognitionmedicine.diseasemeta-analysislcsh:GeneticsAlcoholism030104 developmental biologyMeta-analysisAlcohol intakesex characteristicsTranscriptomebusiness030217 neurology & neurosurgerySex characteristicsGenes
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Methodological advances in the functional profiling of genomic studies

2013

In this thesis we present bioinformatic tools and algorithms for the analysis of genomic data such as those generated by microarray devices or next generation sequencing techniques. Particularly, we develop new approaches to gene set analysis. The described procedures should be useful in practice to tackle complex biological experiments, but hopefully will also be methodologically relevant, as they introduce new ways of conceptualizing genomic functional profiling. Our very flexible approach allows for the inclusion of not just one kind of genomic measurement but many. It makes possible, for instance, to analyze expression measurement and genomic variation data at a time. This multidimensio…

functional profiling:CIENCIAS DE LA VIDA::Genética [UNESCO]:MATEMÁTICAS::Estadística::Análisis de datos [UNESCO]logistic regressionUNESCO::MATEMÁTICAS::Estadística::Análisis multivariantebiostatisticsbioinformaticsUNESCO::MATEMÁTICAS::Estadística::Análisis de datos:CIENCIAS DE LA VIDA::Biometría [UNESCO]ComputingMethodologies_PATTERNRECOGNITIONUNESCO::CIENCIAS DE LA VIDA::Genéticastatistics:MATEMÁTICAS::Estadística::Análisis multivariante [UNESCO]gene set analysisgenomicsUNESCO::CIENCIAS DE LA VIDA::Biometría
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Dinámica de la microbiota en niños, adolescentes y adultos

2022

La microbiota intestinal se implanta a lo largo del desarrollo del individuo y su composición y funciones difieren según la edad. Conocer los cambios que se producen en la microbiota intestinal a lo largo de la vida puede ayudar al diagnóstico, tratamiento y prevención de enfermedades relacionadas con alteraciones metabólicas e inmunitarias. Con este trabajo pretendemos contribuir a la comprensión del proceso de desarrollo de la microbiota intestinal, centrándonos en dos períodos que han recibido poca atención: los primeros años y la adolescencia. Hemos determinado la composición y la función de la microbiota a través de enfoques metagenómicos de genoma completo y basados ​​en ARN ribosómic…

metagenomicsfunctional profilingmicrobiota dynamicsmicrobiota stabilityUNESCO::CIENCIAS DE LA VIDAgut microbiome16S rRNA gene sequencingdiversity analysis:CIENCIAS DE LA VIDA [UNESCO]
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